There is a world-wide epidemic of pulmonary tuberculosis (TB). Once thought to be a near-conquered disease, pulmonary TB is now killing more people than ever, especially those infected with HIV in developing countries.
Although pulmonary TB can be treated and cured with powerful drugs, many sufferers still go untreated because the disease is difficult to detect without sputum tests that can be time-consuming and expensive.
That is why a rapid, accurate, cost-effective, point of care test for pulmonary TB is urgently needed. Breath testing could provide such a test because the mycobacteria that cause pulmonary TB generate a very distinctive pattern of volatile organic compounds (VOCs) when grown in the laboratory.
In a multicenter international study, a six-minute BreathLink breath test accurately identified active pulmonary TB. In clinical practice, a negative result on the breath test could identify people who do not have TB with nearly 100% accuracy.
Two-stage screening with a breath test followed by sputum testing only in those with a positive breath test result could safelycut the costs of finding new cases of active pulmonary TB.
(PDF Document) Point-of-care breath test for biomarkers of active pulmonary tuberculosis.
Phillips M, Basa-Dalay V, Blais J, Bothamley G, Chaturvedi A, Modi KD, Pandya M, Natividad MPR, Patel U, Ramraje NN, Schmitt P, Udwadia ZF
Tuberculosis (May 29, 2012)
(PDF Document) Point-of-Care Breath Test for Biomarkers of Active Pulmonary Tuberculosis.
Blais J, Chaturvedi A, Pandya M, Schmitt P, Bothamley G, Udwadia Z, Natividad M, Dalay V, and Phillips M
Workshop on TB and HIV Diagnostics in Adult and Pediatric Populations, sponsored by NIH and FDA, Silver Spring, MD (June 29, 2011)
(PDF Document) Breath biomarkers of active pulmonary tuberculosis.
Phillips M, Basa-Dalay V, Bothamley G, Cataneo RN, Lam PK, Natividad MPR, Schmitt P, and Wai J
Tuberculosis (Mar. 2, 2010)
(PDF Document) Volatile biomarkers of pulmonary tuberculosis in the breath.
Phillips M, Cataneo RN, Condos R, Erickson GAR, Greenberg J, La Bombardi V, Munawar MI, and Tietje O
Tuberculosis (2007); 87: 44-52.
(PDF Document) Volatile markers of pulmonary tuberculosis in the breath.
Phillips M, Cataneo RN, Condos R, Ring Erickson GA, Greenberg J, and La Bombardi V
European Respiratory Journal (2004); 24: Suppl. 48, 467s